Haematogenous dissemination of pulmonary isolates of M. tuberculosis in animal model—a quantitative measurement
Challu, Vijay Kumar; Chandrashekaran, Sujatha and Chauhan, M.M. (1998) Haematogenous dissemination of pulmonary isolates of M. tuberculosis in animal model—a quantitative measurement. Indian Journal of Tuberculosis, 45. pp. 23-27.
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Measurement of the haematogenous dissemination of tubercle bacilli in the NTI-bred homogeneous stock of albino guinea pigs revealed a significant direct correlation (P<0.001) with the conventional virulence assay method based on Mitchison’s scoring procedure. This study also showed that the modal log value derived from the microbial enumeration of spleen tissue homogenates for the low and moderately virulent isolates (from 163 cases) coincided at 3.699, in comparison with the modal log value of 5.041 for the highly virulent isolates (from 102 cases) of M. tuberculosis.
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