Haematogenous dissemination of pulmonary isolates of M. tuberculosis in animal model—a quantitative measurement

Challu, Vijay Kumar; Chandrashekaran, Sujatha and Chauhan, M.M. (1998) Haematogenous dissemination of pulmonary isolates of M. tuberculosis in animal model—a quantitative measurement. Indian Journal of Tuberculosis, 45. pp. 23-27.

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Abstract

Measurement of the haematogenous dissemination of tubercle bacilli in the NTI-bred homogeneous stock of albino guinea pigs revealed a significant direct correlation (P<0.001) with the conventional virulence assay method based on Mitchison’s scoring procedure. This study also showed that the modal log value derived from the microbial enumeration of spleen tissue homogenates for the low and moderately virulent isolates (from 163 cases) coincided at 3.699, in comparison with the modal log value of 5.041 for the highly virulent isolates (from 102 cases) of M. tuberculosis.

EPrint Type:Article
Uncontrolled Keywords:Tuberculosis, Haematogenous dissemination, Guinea Pigs
Subjects:-Institutional Repositories > National Tuberculosis Institute
Animal Diseases > Disease Models, Animal
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Investigative Techniques > Animal Experimentation
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:685
Deposited By:Librarian Sudha S Murthy
Deposited On:11 August 2005

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