Initial drug resistance to antituberculosis drugs in urban and rural district tuberculosis programme

Chandrasekaran, Sujatha; Jagota, P. and Chaudhuri, K. (1995) Initial drug resistance to antituberculosis drugs in urban and rural district tuberculosis programme. Indian Journal of Tuberculosis, 39. pp. 171-175.

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The proportion of initial drug resistance (IDR) to antituberculosis drugs was estimated among new patients attending urban and rural District Tuberculosis Programme (DTP). For estimating the rural IDR, 398 smear positive patients attending DTP in Kolar district in the sears 1987-89, who were offered Short Course Chemotherapy (SCC) were taken into the study. Sputum specimens collected from them were subjected to culture and drug sensitivity tests. It was observed that IDR to any drug was 34.9% (Isoniazid 32.87% and Rifampicin 4.4%). Among the newly diagnosed urban patients attending the State TB Centre, Bangalore in the year 1985-86, IDR to any drug was 20.57% (Isoniazid 17.35% and Rifampicin 2.89%). Combined resistance to Rifampicin and Isoniazid was 1.36% in the urban clinic and 3.42% in rural DTP. Thus, resistance to Rifampicin was already present in areas where SCC was yet to be introduced, which becomes a source of concern. With the gradual introduction of SCC in NTP and treatment not being restricted strictly to the fresh cases. IDR to Isoniazid and Rifampicin assumes paramount importance and has to be monitored continuously.

EPrint Type:Article
Uncontrolled Keywords:Tuberculosis, Drug therapy, Drug resistance, India
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
Therapeutics > Drug Therapy
Chemical and Pharmacologic Phenomena > Drug Resistance
-Institutional Repositories > National Tuberculosis Institute
Geographic Locations > Asia > Asia, Western > India
Health Care Economics and Organizations > Health Planning > National Health Programs
Persons > Population Groups
Persons > Patients
Environment and Public Health > Public Health > Epidemiologic Methods
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:726
Deposited By:Librarian Sudha S Murthy
Deposited On:17 August 2005

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