The effect of isoniazid in pulmonary tuberculosis as judged by control studies in Indian patients
Frimodt-Moller, J.; Jesudian, K.T.; Muthiah, T.S. and Barton, R.M. (1953) The effect of isoniazid in pulmonary tuberculosis as judged by control studies in Indian patients. Indian Journal of Tuberculosis, 1 (1). pp. 23-32.
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The object of the present investigation has been to determine (i) whether isonicotinic acid hydrazide (or Isoniazid or INAH) has a definite effect on the course of pulmonary tuberculosis, and if so (ii) what would be the minimal effective dose in Indian patients, and (iii) if there would be any advantage in giving INAH in combina-tion with streptomycin (SM). Three series of control studies have been carried out since the end of April 1952 when isoniazid became available. Two studies lasted 12 weeks and the third in which the patients will receive treatment for nine months is not yet completed but a preli-minary analysis of the results up to 26 weeks has been undertaken. The total number of patients submitted to the three studies has been 239.
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