The effect of streptomycin and isoniazid in pulmonary tuberculosis with and without para-amino salicylic acid

Frimodt-Moller, J. (1955) The effect of streptomycin and isoniazid in pulmonary tuberculosis with and without para-amino salicylic acid. Indian Journal of Tuberculosis, 2 (2). pp. 42-57.

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Abstract

In a previous investigation 1 the results of treatment with Isoniazid (INH) alone or in combination with Streptomycin (SM) were compared with the effect of Streptomycin and Para-amino-salicylic acid (PAS). The two-drug treatment appeared to be superior to Isoniazid alone and of the two combinations, the one with Strepto- mycin and Isoniazid appeared to be superior to that of Streptomycin and PAS. It was found that the percentage of patients with tubercle bacilli in sputum could be reduced to about 20 per cent. About half of these produced growth by culture in spite of 40 weeks’ treatment. Most of the strains surviving this long period of treatment were resistant to Streptomycin as well as to Isoniazid. In order to find out whether PAS added to Streptomycin and Isoniazid could further reduce the number of patients which continued to harbour tubercle bacilli after prolonged treatment with Streptomycin and Isoniazid only, a new series of investigations were begun in September 1953. The report of this investigation is presented here.

EPrint Type:Article
Additional Information:Paper read at the Twelfth Tuberculosis Workers’ Conference, Amritsar, February 14-17, 1955.
Uncontrolled Keywords:Streptomycin, Isoniazid, Pulmonary Tuberculosis, Para-Amino Salicylic Acid
Subjects:Therapeutics > Drug Therapy
Organic Chemicals > Hydrazines > Isoniazid
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Pharmaceutical Preparations > Drug Combinations
Organic Chemicals > Carboxylic Acids > Hydroxy Acids > Hydroxybenzoic Acids > Salicylic Acids > Aminosalicylic Acids > p-Aminosalicylic Acid
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:799
Deposited By:Mrs Naina Pandita
Deposited On:28 September 2005

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