The effect of streptomycin and isoniazid in pulmonary tuberculosis with and without para-amino salicylic acid
Frimodt-Moller, J. (1955) The effect of streptomycin and isoniazid in pulmonary tuberculosis with and without para-amino salicylic acid. Indian Journal of Tuberculosis, 2 (2). pp. 42-57.
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In a previous investigation 1 the results of treatment with Isoniazid (INH) alone or in combination with Streptomycin (SM) were compared with the effect of Streptomycin and Para-amino-salicylic acid (PAS). The two-drug treatment appeared to be superior to Isoniazid alone and of the two combinations, the one with Strepto- mycin and Isoniazid appeared to be superior to that of Streptomycin and PAS. It was found that the percentage of patients with tubercle bacilli in sputum could be reduced to about 20 per cent. About half of these produced growth by culture in spite of 40 weeks’ treatment. Most of the strains surviving this long period of treatment were resistant to Streptomycin as well as to Isoniazid. In order to find out whether PAS added to Streptomycin and Isoniazid could further reduce the number of patients which continued to harbour tubercle bacilli after prolonged treatment with Streptomycin and Isoniazid only, a new series of investigations were begun in September 1953. The report of this investigation is presented here.
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