Cyanacetic acid hydrazide in the treatment of drug-resistant pulmonary tuberculosis

Takaro, Timothy and Dry, Satyendralal (1956) Cyanacetic acid hydrazide in the treatment of drug-resistant pulmonary tuberculosis. Indian Journal of Tuberculosis, 3 (3). pp. 86-89.

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Abstract

In the continuing search for new drugs which are effective against M. tuberculosis with minimum toxicity, a number of substances closely related to isonicotinic acid hydrazide chemically have been recently tested. One such chemical, cyanacetic acid hydrazide, (to be referred to hereinafter as CAH) resembles isonicotinic acid hydrazide except for substitution of the pyridine ring in INH for an aliphatic ring. It was thought that this would reduce the toxicity of INH while retaining antimicrobial effectiveness.

EPrint Type:Article
Uncontrolled Keywords:Cyanacetic Acid Hydrazide, Drug-resistant Pulmonary Tuberculosis, Treatment, Pulmonary Tuberculosis, X-Ray Studies, Body Weight, Sputum Studies
Subjects:Heterocyclic Compounds > Acids, Heterocyclic > Isonicotinic Acids
Fluids and Secretions > Bodily Secretions > Sputum
Therapeutics > Drug Therapy
Chemical and Pharmacologic Phenomena > Drug Resistance
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Organic Chemicals > Hydrazines
Pathological Conditions, Signs and Symptoms > Signs and Symptoms > Body Weight Changes
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:813
Deposited By:Mrs Naina Pandita
Deposited On:14 October 2005

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