The combined therapeutic action of isobutyl sulphone (S. No. 47) dihydrostreptomycin aulphate (DHS) and isoniazid (INH) in experimental tuberculosis of guinea-pigs

Gupta, S.K. and Mukerji, B. (1957) The combined therapeutic action of isobutyl sulphone (S. No. 47) dihydrostreptomycin aulphate (DHS) and isoniazid (INH) in experimental tuberculosis of guinea-pigs. Indian Journal of Tuberculosis, 5 (1). pp. 14-19.

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Abstract

The combined effect of administration of 6,12,18 and 24 mg./kg./day of S. N. 47 with DHS 1.5 mg./kg./day or INH 0.4 mg./kg./day were compared with S. N. 47 alone in comparable dosages. As judged macroscopically and histopathologically the combined effect of S. N. 47 with DHS and INH were merely additive and no synergism could be demonstrated.

EPrint Type:Article
Uncontrolled Keywords:Isobutyl Sulphone (S. No. 47), Dihydrostreptomycin Sulphate (DHS), Isoniazid (INH), Therapeutic Action, Experimental Tuberculosis, Guinea-Pigs
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
Therapeutics > Drug Therapy
Organic Chemicals > Hydrazines > Isoniazid
Investigative Techniques > Animal Experimentation
Pharmaceutical Preparations > Drug Combinations
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
Organic Chemicals > Sulfur Compounds > Sulfones
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:842
Deposited By:Mrs Naina Pandita
Deposited On:08 November 2005

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