Studies on nutrition in experimental tuberculosis
Sirsi, M. (1958) Studies on nutrition in experimental tuberculosis. Indian Journal of Tuberculosis, 5 (2). pp. 47-52.
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Some natural diets of different nutritional values, when given in adequate quantities do not influence the course of acute experimental tuberculosis of mice. While moderate diminution of dietetic intake from the time of infection caused no appreciable change in the survival time, a preliminary acute starvation followed by an inadequate diet, to the extent of one-fourth of the normal and of chronic starvation prior to infection had an adverse effect on the survival period. Further reduction in the diet causes earlier mortality more by the metabolic effects of starvation rather than by any enhancement in the severity and extent of the lesions. The influence of deficient diet on the development of hypersensitivity to tuberculin and on the phagocytic activity of the monomuclear cells would throw more light on some of the immunological phenomenon associated with tuberculosis. The role of these diets in milder types of infection, wherein an equilibrium in host parasite relationship is established and on the cellular and humoral factors in re-infection as also on the hypersensitivity reaction needs elucidation.
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