The present position of freeze-dried BCG vaccine
Ranganathan, K.S. (1958) The present position of freeze-dried BCG vaccine. Indian Journal of Tuberculosis, 5 (3). pp. 102-114.
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1. The factors that influence the survival of B.C.G. after freeze drying and storage, and the measures taken to minimize loss of viable bacilli are mentioned. 2. Attention is drawn to the observed variations in the viability of dried vaccines not only from different sources, but even of the same origin. 3. Further studies are needed to determine the optimum level of allergy to be obtained by B.C.G. vaccination and the appropriate dose of vaccine that will produce it under standardised conditions of tuberculin testing. 4. There can be no doubt of the future of freeze-dried vaccine if the methods of production can be further improved and the laboratory assay of the vaccines well standardized.
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