Further experience with viomycin, pyrazinamide and cycloserine in the treatment of pulmonary tuberculosis
Banerjee, K. and Fletcher, A.G. (1960) Further experience with viomycin, pyrazinamide and cycloserine in the treatment of pulmonary tuberculosis. Indian Journal of Tuberculosis, 7 (2). pp. 64-72.
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A treatment-failure group of 115 patients were re-treated with either viomycin, pyrazinamide or cycloserine in combination with isoniazid. In 45 cases, these drugs were used to provide anti-microbial coverage for surgical intervention, with excellent results and a low Incidence of operative complications. Among 70 patients who were not suitable for surgical intervention, only 13 had good results. There was one case of hepato-toxicity in the pyrazinamide group, 5 cases of mild or severe psychosis in the cycloserine group, and one case of severe drug sensitivity reaction in the viomycin group.
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