Catalase and peroxidase in acid-fast bacilli and their relation to drug sensitivity
Prakash, Om; Krishnan, C. and Ghosh Ray, B. (1960) Catalase and peroxidase in acid-fast bacilli and their relation to drug sensitivity. Indian Journal of Tuberculosis, 7 (4). pp. 88-94.
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Twenty-nine strains of acid-fast bacilli including saprophytes and atypical strains were tested for drug sensitivity in vitro against Isoniazid, PAS and Streptomycin. The results were correlated with their catalase and peroxidase activity. The quantitative determination of catalase wis done at pH 1 and pH 7 to see if these Mycobacteria could be classified on this basis. Catalase activity was well correlated with Isoniazid sensitivity in the human strains of this series except in one strain. Peroxidase activity was correlated with Isoniazid sensitivity in all strains except one human and three atypical strains. It seems that catalase activity at pH 1 and pH 7 cannot be relied upon to identify unclassified mycobacteria.
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