A concurrent comparison of four regimens of chemotherapy in the domiciliary treatment of pulmonary tuberculosis in South India

Ramakrishnan, C.V. and Velu, S. (1961) A concurrent comparison of four regimens of chemotherapy in the domiciliary treatment of pulmonary tuberculosis in South India. Indian Journal of Tuberculosis, 8 (3). pp. 114-119.

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Abstract

The combination of isoniazid plus PAS has been found to be a most satisfactory and effective form of treatment for pulmonary tuberculosis in the domiciliary management of patients drawn from the poor urban community of Madras city. Treatments consisting of isoniazid alone given daily in two equally divided doses, whether it was 400 mg or 200 mg per day, have not proved to be very satisfactory forms of chemotherapy. The high dose of isoniazid (7.8 to 9.6 mg/kg) given as a single dose was more effective than the other two isoniazid alone regimens but it was associated with a high incidence of toxic complication in the shape of peripheral neuritis.

EPrint Type:Article
Additional Information:Paper presented by C.V. Ramakrjshnan at the XVII All India Tuberculosis & Chest Diseases Workers’ Conference held at Cuttack in January 1961.
Uncontrolled Keywords:Regimens, Chemotherapy, Domiciliary Treatment, Pulmonary Tuberculosis, South India, Isoniazid, PAS
Subjects:Disorders of Environmental Origin > Poisoning > Drug Toxicity
Therapeutics > Drug Therapy
Organic Chemicals > Hydrazines > Isoniazid
Health Care Facilities, Manpower, and Services > Health Services > Community Health Services > Home Care Services
Investigative Techniques > Toxicity Tests
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Pharmaceutical Preparations > Drug Combinations
Organic Chemicals > Carboxylic Acids > Hydroxy Acids > Hydroxybenzoic Acids > Salicylic Acids > Aminosalicylic Acids > p-Aminosalicylic Acid
Investigative Techniques > Drug Administration Schedule
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:910
Deposited By:Mrs Naina Pandita
Deposited On:23 September 2005

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