Effect of some amino acid antagonists on the ‘in vitro’ growth of Mycobacterium tuberculosis H37RV
Indira, M. and Sirsi, M. (1961) Effect of some amino acid antagonists on the ‘in vitro’ growth of Mycobacterium tuberculosis H37RV. Indian Journal of Tuberculosis, 8 (4). pp. 150-154.
Full text available as:
The effect of the amino acid antagonists, ethionine, methionine sulphoxide, 6- methyl tryptophan, cysteic acid and β -amino butyric acid on the growth of Mycobacterium tuberculosis H37RV in asparagine media and in media containing their specific metabolites has been studied. Ethionine and 6-methyl tryptophan, besides being inhibitory to their specific metabolites which were not by themselves good supporters of growth, exhibit powerful antagonism to the growth of tubercle bacilli in asparagine media also. Ethionine at 10 γ /ml and 6-methyltryptophan at l00 γ /ml cause complete inhibition of growth due to l0mg./ml. of asparagine. Methionine sulphoxide, cysteic acid and β -amino butyric acid exert no appreciable influence in either specific antagonism or on in asparagine. The nature of the inhibition whether competitive or irreversible is under investigation.
Archive Staff Only: edit this record