The virulence in the guinea-pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis: comparision with virulence of tubercle bacilli from British patients

Bhatia, A.L.; Csillag, Anna; Mitchison, D.A.; Selokon, J.B.; Somasundaram, P.R. and Subbiah, T.V. (1961) The virulence in the guinea-pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis: comparision with virulence of tubercle bacilli from British patients. Indian Journal of Tuberculosis, 9 (1). pp. 3-14.

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Abstract

A series of studies has been undertaken by the Tuberculosis Chemotherapy Centre Madras, with the ultimate object of finding out whether differences in the virulence of the tubercle bacilli isolated from Indian tuberculous patients before the start of chemotherapy are related to the severity of the patients’ disease and to the subsequent response to treatment. This paper presents the results of a comparative investigation of the virulence in the guinea-pig of tubercle bacilli obtained from Indian and from British tuberculous patients before treatment. In this investigation, which was carried out at the Centre and at the Micro-biological Research Establishment, Porton, England, the virulence of the Indian and the British cultures was assessed by guinea-pig mortality, by the ‘root-index of virulence’ (based on the post-mortem tuberculous disease score and the survival period of the animal), and by the results of spleen culture. The Indian cultures were found, on the average, to be less virulent and to show a wider range of virulence than the British cultures, both in the Porton and in the Madras series of experiments. A further indication of the heterogeneity of the Indian tubercle bacilli was provided by the results of tuberculin tests: whereas the British cultures appeared to be homogeneous in their ability to induce tuberculin allergy in the guinea-pig, the Indian cultures showed considerable variation in this respect.

EPrint Type:Article
Uncontrolled Keywords:Virulence, Tubercle bacill, India, Patients, South India, Comparision, British Patients, Guinea-pig
Subjects:Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Investigative Techniques > Animal Experimentation
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Investigative Techniques > Clinical Laboratory Techniques > Culture Techniques
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
Geographic Locations > Europe > Great Britain
Biological Phenomena, Cell Phenomena, and Immunity > Biological Phenomena
Immunologic and Biological Factors > Biological Factors > Virulence Factors
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:915
Deposited By:Mrs Naina Pandita
Deposited On:21 September 2005

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