The virulence in the guinea-pig of isoniazid-sensitive tubercle bacilli isolated from South Indian patients before treatment and after three months of chemotherapy

Subbiah, T.V.; Bhatia, A.L.; Geraghty, Ellen; Mitchison, D.A.; Radhakrishnan, S. and Selkon, J.B. (1962) The virulence in the guinea-pig of isoniazid-sensitive tubercle bacilli isolated from South Indian patients before treatment and after three months of chemotherapy. Indian Journal of Tuberculosis, 9 (2). pp. 45-49.

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Abstract

In order to find out whether chemotherapy with isoniazid affects the virulence in the guinea-pig of tubercle bacilli that do not develop resistance to the drug, virulence tests were carried out on isoniazid-sensitive cultures obtained from 20 South Indian tuberculous patients before treatment and after three months of chemotherapy with isoniazid. No significant difference in virulence was observed between the cultures obtained on admission to treatment and those obtained after three months of chemotherapy. This is a finding with important implications for large-scale surveys of the distribution of attenuated strains of tubercle bacilli from untreated patients in India and other countries. Detailed and repeated inquiries as to previous chemo-therapy are not important in such surveys, provided that sensitivity tests are done on all the cultures.

EPrint Type:Article
Uncontrolled Keywords:Virulence, Guinea-pig, Chemotherapy, Isoniazid-Sensitive, Tubercle Bacilli, South India, Patients, Untreated Patients
Subjects:Therapeutics > Drug Therapy
Organic Chemicals > Hydrazines > Isoniazid
Geographic Locations > Asia > Asia, Western > India
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium
Immunologic Diseases > Hypersensitivity > Drug Hypersensitivity
Investigative Techniques > Clinical Laboratory Techniques > Culture Techniques
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
Investigative Techniques > Drug Administration Schedule
Immunologic and Biological Factors > Biological Factors > Virulence Factors
Persons > Patients
ID Code:918
Deposited By:Mrs Naina Pandita
Deposited On:21 September 2005

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