Identification of tubercle bacilli from Indian patients with pulmonary tuberculosis

Thomas, K.L; Joseph, S.; Subbiah, T.V. and Selkon, J.B. (1962) Identification of tubercle bacilli from Indian patients with pulmonary tuberculosis. Indian Journal of Tuberculosis, 9 (2). pp. 99-110.

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Pretreatment cultures of bacilli from Indian patients with active pulmonary tuberculosis admitted to a controlled domiciliary chemotherapy study by the Tuberculosis Chemotherapy Centre, Madras, were subjected to a series of in vitro tests designed to identify the bacilli as human or bovine tubercle bacilli, or as anonymous mycobacteria. For the purposes of comparison, pretreatment cultures from British patients with pulmonary tuberculosis were examined by the same series of identification tests. Cultures identifiable as mammalian tubercle bacilli were obtained from all the 341 Indian patients admitted to the chemotherapy study. Tests for niacin production were carried out on the cultures from 277 of these patients; all gave positive results, indicating that the bacilli in question were Mycobacterium tuberculosis var. hominis. The cultures from the Indian patients yielded results similar to those of the cultures from the British patients in all the in vitro tests except the thiacetazone-sensitivity test. In this test the Indian cultures differed from the British cultures, being on the average less sensitive and showing greater variation in sensitivity among themselves.

EPrint Type:Article
Uncontrolled Keywords:Tubercle bacilli, Pulmonary Tuberculosis, Isolation, Pretreatment Cultures, Domiciliary Chemotherapy, Indian Patients, British Patients, Chemotherapy
Subjects:Fluids and Secretions > Bodily Secretions > Sputum
Therapeutics > Drug Therapy
Geographic Locations > Asia > Asia, Western > India
Equipment and Supplies > Culture Media
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Health Care Facilities, Manpower, and Services > Health Services > Community Health Services > Home Care Services
Investigative Techniques > Animal Experimentation
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Investigative Techniques > Clinical Laboratory Techniques > Culture Techniques
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
Geographic Locations > Europe > Great Britain
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:921
Deposited By:Mrs Naina Pandita
Deposited On:20 September 2005

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