Rate of inactivation of isoniazid in South Indian patients with pulmonary tuberculosis: microbial assay of isoniazid in serum following a standard intramuscular dose

Gangadharam, P. R. J.; Bhatia, A.L.; Radhakrishnan, S. and Selkon, J.B. (1962) Rate of inactivation of isoniazid in South Indian patients with pulmonary tuberculosis: microbial assay of isoniazid in serum following a standard intramuscular dose. Indian Journal of Tuberculosis, 9 (2). pp. 111-123.

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Abstract

Since isoniazid is metabolized in man to several derivatives with little or no specific activity against the tubercle bacillus, its rate of inactivation in the body may have an important bearing on its efficacy as an antituberculosis drug. The inactivation rate, though constant in any one person, is known to vary from individual to individual and from race to race. A series of studies on the rate of inactivation of isoniazid in Indian patients with pulmonary tuberculosis has recently been undertaken at the Tuberculosis Chemotherapy Centre, Madras. The present paper describes the first of these studies, in which the concentration of isoniazid in the serum of patients admitted to a controlled comparison of four domiciliary chemotherapeutic regimens was determined by microbiological assay four-and-a-half hours after administration of a standard dose of isoniazid (3 mg/kg body-weight). Patients with serum levels of 0.58 µg/ml or more were classified as slow inactivators of isoniazid and those with levels below 0.58 µg/ml as rapid inactivators. By this definition, 195 (61 per cent) of the 321 patients studied were found to be slow inactivators and 126 (39 per cent) rapid inactivators. A relationship was shown between sex and the rate of inactivation, there being a significantly higher proportion of rapid inactivators among the females than among the males. The observed estimates of the error of the microbiological assay procedure are discussed and possible ways of reducing the error suggested.

EPrint Type:Article
Uncontrolled Keywords:Isoniazid, Inactivation Rate, Serum, South India, Patients, Microbial Assay, Intramuscular Dose, Metabolism
Subjects:Therapeutics > Drug Therapy
Genetic Phenomena > Sex Ratio
Organic Chemicals > Hydrazines > Isoniazid
Geographic Locations > Asia > Asia, Western > India
Health Care Facilities, Manpower, and Services > Health Services > Community Health Services > Home Care Services
Investigative Techniques > Drug Administration Routes
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Biochemical Phenomena, Metabolism, and Nutrition > Metabolism
Investigative Techniques > Drug Administration Schedule
Hemic and Immune Systems > Blood
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:922
Deposited By:Mrs Naina Pandita
Deposited On:20 September 2005

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