The virulence in the guinea-pig of tubercle bacilli isolate before treatment from South Indian patients with pulmonary tuberculosis: virulence related to pretreatment status of disease and to response to chemotherapy

Ramakrishnan, C.V.; Bhatia, A.L.; Fox, Wallace; Mitchison, D.A.; Radhakrishnan, S.; Selkon, J.B.; Subbiah, T.V.; Velu, S. and Wallace, J.G. (1962) The virulence in the guinea-pig of tubercle bacilli isolate before treatment from South Indian patients with pulmonary tuberculosis: virulence related to pretreatment status of disease and to response to chemotherapy. Indian Journal of Tuberculosis, 9 (2). pp. 124-139.

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Abstract

This is the last of a series of three reports from the Tuberculosis Chemotherapy Centre Madras, on a study undertaken with the object of finding out whether differences in the virulence in the guinea-pig of tubercle bacilli isolated from South Indian tuberculous patients before the start of chemotherapy are related to the severity of the patients’ disease on admission to treatment and to the subsequent response to chemotherapy. The 281 patients in this study were drawn from the patients admitted to a 1-year comparison of four domiciliary chemotherapeutic regimens: (a) 3.9-5.5 mg/kg isoniazid plus 0.2-0.3 g/kg sodium PAS daily, divided into two doses (PH series); (b) 7.8-9.6 mg/kg isoniazid alone daily in one dose (HI-1 series); (c) 7.8-9.6 mg/kg isoniazid alone daily, divided into two doses (HI-2 series); (d) 3.9-5.5 mg/kg isoniazid alone daily, divided into two doses (H series). No evidence was found of an association between the virulence of the organisms and any pretreatment condition of known prognostic importance. There was no association between pretreatment virulence and progress during treatment in the PH series (the most effective regimen). In the other series, however, the progress was more satisfactory in patients infected with organisms of low virulence than in those infected with organisms of high virulence, the association between virulence and progress attaining statistical significance in the combined HI-2 and H series (the least effective regimens) and only just failing to do so in the smaller HI-1 series. Possible explanations are put forward both for the absence of an association between virulence and severity of disease on admission and for the presence of an association between virulence an response in the patients treated with isoniazid alone.

EPrint Type:Article
Uncontrolled Keywords:Virulence, Tubercle Bacilli, Pretreatment, Pulmonary Tuberculosis, Guinea Pigs, South Indian Patients, Domiciliary Chemotherapeutic Regimens, Chemotherapy, Isoniazid, Sodium PAS
Subjects:Therapeutics > Drug Therapy
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Health Care Facilities, Manpower, and Services > Health Services > Community Health Services > Home Care Services
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Pharmaceutical Preparations > Drug Combinations
Organic Chemicals > Carboxylic Acids > Hydroxy Acids > Hydroxybenzoic Acids > Salicylic Acids > Aminosalicylic Acids > p-Aminosalicylic Acid
Biological Phenomena, Cell Phenomena, and Immunity > Biological Phenomena
Investigative Techniques > Drug Administration Schedule
Immunologic and Biological Factors > Biological Factors > Virulence Factors
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:923
Deposited By:Mrs Naina Pandita
Deposited On:20 September 2005

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