INH resistant human tubercle bacilli

Mahapatra, B. (1964) INH resistant human tubercle bacilli. Indian Journal of Tuberculosis, 12 (2). pp. 57-60.

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Abstract

One hundred and nine strains of human tubercle bacilli were studied of whom 91 were INH resistant. These resistant variants in most cases developed in the patients during the course of treatment. These resistant strains did not show an increased degree of loss of niacin synthesising power. None of them possessed both catalase and peroxidase. 16.48 per cent of them lost their catalase activity whereas peroxidase action was lost in 97.79 per cent. Out of the latter group 57.14 per cent showed mixed type of colonies in their culture, some still possessing the peroxidase activity. These resistant variants were virulent to mice in (97.79 per cent) and to guineapigs in (78.02 per cent). There was no correlation between the pathogenicity and the production of catalase and peroxidase.

EPrint Type:Article
Uncontrolled Keywords:INH Resistance, Tubercle Bacilli, Human, Pathogenecity, Catalase, Peroxidase
Subjects:Fluids and Secretions > Bodily Secretions > Sputum
Chemical and Pharmacologic Phenomena > Drug Resistance
Organic Chemicals > Hydrazines > Isoniazid
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Enzymes and Coenzymes > Enzymes > Oxidoreductases
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Investigative Techniques > Clinical Laboratory Techniques > Culture Techniques
Immunologic and Biological Factors > Biological Factors > Virulence Factors
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:966
Deposited By:Mrs Naina Pandita
Deposited On:07 December 2005

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