INH resistant human tubercle bacilli
Mahapatra, B. (1964) INH resistant human tubercle bacilli. Indian Journal of Tuberculosis, 12 (2). pp. 57-60.
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One hundred and nine strains of human tubercle bacilli were studied of whom 91 were INH resistant. These resistant variants in most cases developed in the patients during the course of treatment. These resistant strains did not show an increased degree of loss of niacin synthesising power. None of them possessed both catalase and peroxidase. 16.48 per cent of them lost their catalase activity whereas peroxidase action was lost in 97.79 per cent. Out of the latter group 57.14 per cent showed mixed type of colonies in their culture, some still possessing the peroxidase activity. These resistant variants were virulent to mice in (97.79 per cent) and to guineapigs in (78.02 per cent). There was no correlation between the pathogenicity and the production of catalase and peroxidase.
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