The relative merits of various virulence tests for mycobacteriaMahapatra, B. (1964) The relative merits of various virulence tests for mycobacteria. Indian Journal of Tuberculosis, 11 (4). pp. 172-176. Full text available as:
AbstractOne hundred and twenty-five strains of mycobacteria freshly isolated from clinical cases of pulmonary tuberculosis were sub- jected to animal pathogenicity, cording and neutral-red tests in order to establish their relative virulence. In another 6.4 per cent strains our findings were rather unusual. These strains were INH resistant, all forming poor quality of cords and three showing negative mice pathogenicity. The probability for such unusual result is explained. Since all the tests show variation, a better evaluation of virulence can be made by studying more than one property rather than any single one. The combined study of cytochemical reaction and cord formation gives as much information as animal pathogenicity with definite advantage and can be adopted in practice.
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