An in vitro study on sensitivity of tubercle bacilli to thiacetazone
Rao, K.P; Nair, S.S.; Naganathan, N. and Rao, Ramanathan (1966) An in vitro study on sensitivity of tubercle bacilli to thiacetazone. Indian Journal of Tuberculosis, 13 (4). pp. 147-157.
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The effect of bacillary concentration and length of incubation on TB1 drug sensitivity test was investigated on 735 cultures of Mycobacterium tuberculosis human, isolated from patients presumably had no previous treatment with TB1. Both the factors were found to influence the minimal drug inhibitory concentration. The standard sensitive strain H37RV and wild strains were shown to be inhibited over a wide range of concentrations of the drug. Such a graded response of the strains that in cultures having mixed population of is likely to offer difficulty in classifying sensitive cultures from the resistant.
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